Moorpark is served by Metrolink, a train that takes commuters to downtown Los Angeles, with stops in the San Fernando Valley, including Burbank Airport. The Burbank, Van Nuys and Oxnard commuter airports are within 40 minutes of Moorpark. Los Angeles International Airport is only a 60-minute drive. The Southern Pacific rail system provides convenient freight and passenger service to extended U.S. and Canadian markets. Amtrak provides rail service as far south as San Diego and as far north as Seattle, Washington.

Moorpark is directly served by two freeways and one highway, with immediate connections to five major freeways.